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The above-mentioned cylindrical, conical, and inverse conical molecule structures account for neutral, positive, and negative curvatures, respectively, which favor different lipid organizations as shown here
Under identical conditions, if we replace the PC bilayer by a more negative curvature
Whereas by replac- ing DC18 1 PC bilayer with DOPE bilayer bearing a relatively more negative cur- vature with comparable thickness [52] we observe much less reduction in the gA channel lifetime for both short and long gA channels, and the stepwise introduc- tion of DOPE (0, 50, and 100 %) over DC18 1 PC we observe that the gA chan- nel lifetime decreases almost linearly with an increasing negative curvature (see Fig. 5.13).
The additional free energy (6Gnc→i kBT ln ri ) (see earlier section) involved in raising any current level in an Alm channel in thicker bilayers or bilayers with higher amounts of negative curvature is perhaps compensated by the requirement of a higher MAlm [92].
The higher concentration MAlm required in thicker bilayers or bilayers containing lipids with negative curvature or charges are likely to change the free energy profile in bilay- ers [92] which compensates for the changed values of the theoretically calculated 6GI,II .
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